Oxidative stress sensing and response in neural stem cell fate. Academic Article uri icon

Overview

abstract

  • Neural stem/progenitor cells (NSPCs) contribute to the physiological cellular turnover of the adult brain and make up its regenerative potential. It is thus essential to understand how different factors influence their proliferation and differentiation to gain better insight into potential therapeutic targets in neurodegenerative diseases and traumatic brain injuries. Recent evidences indicate the roles of redox stress sensing and coping mechanisms in mediating the balance between NSPC self-renewal and differentiation. Such mechanisms involve direct cysteine modification, signaling and metabolic reprogramming, epigenetic alterations and transcription changes leading to adaptive responses like autophagy. Here, we discuss emerging findings on the involvement of redox sensors and effectors and their mechanisms in influencing changes in cellular redox potential and NSPC fate.

publication date

  • April 18, 2021

Research

keywords

  • Neural Stem Cells

Identity

Scopus Document Identifier

  • 85104593895

Digital Object Identifier (DOI)

  • 10.1016/j.freeradbiomed.2021.03.043

PubMed ID

  • 33862161

Additional Document Info

volume

  • 169