Jihye Paik   Associate Professor of Pathology and Laboratory Medicine

  • +1 212 746 6151

My research at WCM centers on the biology of two important cancer-relevant pathways: PI3K-AKT-FOXO and stem cell differentiation pathways. Over the past few years, I have systematically probed the physiological and pathological roles of the FOXO transcription factor family (Cell 2007, Cell Stem Cell 2009). Using mouse genetic models, stem cell transgenesis, genomics, and metabolomics, I have defined the function and mechanism by which FOXO acts to prevent cancer and maintain stem cell homeostasis (EMBO 2013). We have similarly directed our efforts towards the discovery of novel regulatory factors that serve as breakpoints for cancer and aging. We identified and characterized ZNF365 as a novel regulator of telomere replication and genomic stability, and reported that its expression predicts a better prognosis for cancer patients (Cancer Discovery 2013). Our current goal is to understand the molecular mechanisms regulating stem cell fate, which are intimately linked to cancer, with the hope of applying these principles to the development of cancer therapeutics. 



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Funding awarded

  • Identification of FOXO1 inhibitor for B cell lymphoma therapy (SRA)  awarded by FORKHEAD BIOTHERAPEUTICS, INC. Principal Investigator 2019 - 2020
  • Mechanisms underlying integrated stress response induced inflammation  awarded by National Institute on Aging Principal Investigator 2019 - 2020
  • Longitudinal functional genomics in mantle cell lymphoma therapy and drug resistance  awarded by Leukemia & Lymphoma Society, Inc. Co-Principal Investigator 2018 - 2022
  • Mechanism-Based Targeting of Mantle Cell Lymphoma  awarded by National Cancer Institute Key Personnel 2018 - 2023



Primary Email

  • jep2025@med.cornell.edu


Awards and honors