Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. Academic Article uri icon

Overview

abstract

  • Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors. Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.

authors

publication date

  • September 21, 2014

Research

keywords

  • Adenocarcinoma
  • Models, Molecular
  • Protein Kinase C
  • Salivary Gland Neoplasms

Identity

Scopus Document Identifier

  • 84908867220

Digital Object Identifier (DOI)

  • 10.1038/ng.3096

PubMed ID

  • 25240283

Additional Document Info

volume

  • 46

issue

  • 11