A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection. Academic Article uri icon

Overview

abstract

  • We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of individuals of European descent, with one cohort comprised of female twins donating samples longitudinally. Sample metabolite concentrations were quantified by (1)H NMR and tested for association with genome-wide single-nucleotide polymorphisms (SNPs). Four metabolites' concentrations exhibited significant, replicable association with SNP variation (8.6×10(-11)

publication date

  • September 8, 2011

Research

keywords

  • Genome-Wide Association Study
  • Metabolic Networks and Pathways
  • Metabolome
  • Quantitative Trait Loci
  • Selection, Genetic

Identity

PubMed Central ID

  • PMC3169529

Scopus Document Identifier

  • 80053456207

Digital Object Identifier (DOI)

  • 10.1371/journal.pgen.1002270

PubMed ID

  • 21931564

Additional Document Info

volume

  • 7

issue

  • 9