Cutting Edge: CD28 controls dominant regulatory T cell activity during active immunization. Academic Article uri icon

Overview

abstract

  • Ligation of CD28 during Ag recognition plays an important role in the generation of effective T cell responses. However, its peripheral control of regulatory T cell function remains obscure. In this study, we show that naive wild-type or CD28(-/-) CD4(+)CD25(-) T cells exposed to peptide in vivo develop regulatory activity that suppresses the response of adoptively transferred naive T cells to a subsequent immunogenic challenge. We find that although CD28 is engaged during the initial peptide-priming event and is essential to sustain T cell survival, it is not sufficient to prevent the dominance of regulatory T cell function. Immunization with adjuvant abrogates regulatory dominance, reducing overall Foxp3 expression in a CD28-dependent manner. We conclude that CD28 licenses active immunization by regulating Ag-induced immunoregulation.

publication date

  • March 15, 2006

Research

keywords

  • CD28 Antigens
  • T-Lymphocytes, Regulatory
  • Vaccination

Identity

Scopus Document Identifier

  • 33644843085

PubMed ID

  • 16517696

Additional Document Info

volume

  • 176

issue

  • 6