Matthew Blake Greenblatt   Assistant Professor of Pathology and Laboratory Medicine

  • +1 212 746 2040


Sort by

Selected publications


research overview

  • Approximately half of all women and a fifth of all men will experience a skeletal fracture due to low bone mass.  These fractures kill as many women each year as breast cancer. Improving clinical outcomes in this area will ultimately require finding new therapeutic agents that promote the activity of osteoblasts, the cells that build bone, which in turn will require improving our understanding of the molecular pathways involved in this process.  To this end, we are focused on using a combination of genetics, cellular biochemistry and genome-wide screening to discover new molecular pathways that regulate the activity of osteoblasts.  In particular, we are interested in how tuning the activity of the genes involved in the ability of osteoblasts to perceive signals from their environment can control the formation of bone, focusing  on an ancient and fundamentally important family of signaling molecules, the mitogen activated protein kinases (MAPKs).  Currently, we are exploring how dysregulation of MAPK signaling contributes to skeletal disease and how MAPK pathways can be targeted to benefit bone health.

Grants awarded

  • Assessment of MEKK2 as a Novel Therapeutic Target in Neurofibromatosis  awarded by United States Department of Defense Principal Investigator 2016 -
  • Modulation of Bone Formation by SHN3  awarded by National Institutes of Health, Office of the Director Principal Investigator 2015 -
  • Novel Mechanisms of Bone Formation  awarded by Burroughs Wellcome Fund Principal Investigator 2015 -
  • Identification and Characterization of Bone-Related Genetic Variants in Families  awarded by Qatar National Research Fund Key Personnel 2015 -
  • Bone, Osteoblasts, Osteoclasts, Signal Transduction, Mitogen Activated Protein Kinases



full name

  • Dr. Matthew Blake Greenblatt,

primary email



Primary Affiliation

  • Weill Cornell Medical College, Cornell University

Awards and honors