Dana Leifer Associate Professor of Neurology

Positions

Associate Professor of Neurology, Neurology, Weill Cornell Medical College 2005 -

Dr. Leifer's research currently focuses on development of therapies for acute stroke, for prevention of recurrent stroke, and for rehabilitation after stroke and on functional MRI studies of brain activity during recovery from stroke. His research interests also include the roles of adhesion molecules and tissue-specific transcription factors in neuronal differentiation and regeneration and immunohistochemical studies of stroke and other neurological diseases. In addition, Dr. Leifer serves as an advisor to the New York State Department of Health and the American Heart Association on the development of guidelines for the certification of stroke centers and on the evaluation of stroke center performance.

Publications

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Publications authored

Cerebrovascular reserve and stroke risk in patients with carotid stenosis or occlusion: a systematic review and meta-analysis. Stroke; a journal of cerebral circulation. 2884-2891. 2012 Review GET IT
Times cited: 7
Metrics for measuring quality of care in comprehensive stroke centers: detailed follow-up to Brain Attack Coalition comprehensive stroke center recommendations: a statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke; a journal of cerebral circulation. 42(3):849-877. 2011 Academic Article GET IT
Times cited: 48
Stroke. Encyclopedia of Neuroscience. 2010 Chapter GET IT
Blindness and necrotizing fasciitis after liposuction and fat transfer. Plastic and reconstructive surgery. 126(4):1358-1363. 2010 Academic Article GET IT
Times cited: 2
ACCF/AHA Clopidogrel clinical alert: approaches to the FDA "boxed warning": a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents and the American Heart Association. Circulation. 122(5):537-557. 2010 Academic Article GET IT
Times cited: 90
ACCF/AHA clopidogrel clinical alert: approaches to the FDA "boxed warning": a report of the American College of Cardiology Foundation Task Force on clinical expert consensus documents and the American Heart Association endorsed by the Society for Cardiovascular Angiography and Interventions and the Society of Thoracic Surgeons. Journal of the American College of Cardiology. 321-341. 2010 Conference Paper GET IT
Times cited: 130
High-dose lovastatin for acute ischemic stroke: results of the phase I dose escalation neuroprotection with statin therapy for acute recovery trial (NeuSTART). Cerebrovascular diseases (Basel, Switzerland). 28(3):266-275. 2009 Academic Article GET IT
Times cited: 21
The Neuroprotection with Statin Therapy for Acute Recovery Trial (NeuSTART): an adaptive design phase I dose-escalation study of high-dose lovastatin in acute ischemic stroke. International journal of stroke : official journal of the International Stroke Society. 3(3):210-218. 2008 Academic Article GET IT
Times cited: 22
Quality improvement in acute stroke: the New York State Stroke Center Designation Project. Neurology. 2007 Comment GET IT
Quality improvement in acute stroke: the New York State Stroke Center Designation Project. Neurology. 67(1):88-93. 2006 Academic Article GET IT
Times cited: 72
Aortic arch replacement for recurrent cerebral embolization. Annals of Thoracic Surgery. 73(1):291-294. 2002 Academic Article GET IT
Times cited: 4
Functional regulatory regions of human transcription factor MEF2C. Brain research. Molecular brain research. 97(1):70-82. 2001 Academic Article GET IT
Times cited: 11
Aspirin to prevent strokes: fact or fiction?. Health news (Waltham, Mass.). 2000 Academic Article GET IT
Neuronal plasticity and recovery from stroke. Neuroscientist. 1998 Academic Article
Evaluation of motion correction algorithms in analysis of FMRI studies of motor tasks in stroke patients. NeuroImage. 1997 Academic Article
Myocyte-specific enhancer binding factor 2C expression in fetal mouse brain development. Journal of Molecular Neuroscience. 8(2):131-143. 1997 Academic Article GET IT
Times cited: 6
Myocyte-specific enhancer binding factor 2C expression in gerbil brain following global cerebral ischemia. Neuroscience. 70(1):67-77. 1996 Academic Article GET IT
Times cited: 9
Transcription factors in development of the cerebral cortex. Neuroscientist. 1996 Report
An astrocytic binding site for neuronal Thy-1 and its effect on neurite outgrowth. Proceedings of the National Academy of Sciences of the United States of America. 92(24):11195-11199. 1995 Academic Article GET IT
Times cited: 24
Assignment of human myocyte-specific enhancer binding factor 2C (hMEF2C) to human chromosome 5q14 and evidence that MEF2C is evolutionarily conserved. Genomics. 29(3):809-811. 1995 Academic Article GET IT
Times cited: 1
Myocyte-specific enhancer binding factor 2C expression in human brain development. Neuroscience. 63(4):1067-1079. 1994 Academic Article GET IT
Times cited: 56
Immunohistochemical patterns of selective cellular vulnerability in human cerebral ischemia. Journal of the neurological sciences. 119(2):217-228. 1993 Academic Article GET IT
Times cited: 39
hMEF2C gene encodes skeletal muscle- and brain-specific transcription factors. Molecular and cellular biology. 13(4):2564-2577. 1993 Academic Article GET IT
Times cited: 140
MEF2C, a MADS/MEF2-family transcription factor expressed in a laminar distribution in cerebral cortex. Proceedings of the National Academy of Sciences of the United States of America. 90(4):1546-1550. 1993 Academic Article GET IT
Times cited: 115
Leptomeningeal myelomatosis presenting with mental status changes and other neurologic findings. Cancer. 70(7):1899-1904. 1992 Academic Article GET IT
Times cited: 31
Parietal pseudothalamic pain syndrome. Clinical features and anatomic correlates. Archives of neurology. 49(10):1032-1037. 1992 Academic Article GET IT
Times cited: 90
Familial bilateral carpal tunnel syndrome: report of two families. Archives of physical medicine and rehabilitation. 73(4):393-397. 1992 Academic Article GET IT
Times cited: 8
Selectivity of Thy-1 monoclonal antibodies in enhancing neurite outgrowth. Neuroscience letters. 137(1):75-77. 1992 Academic Article GET IT
Times cited: 10
Thy-1 in hippocampus: normal anatomy and neuritic growth in Alzheimer's disease. Journal of neuropathology and experimental neurology. 51(2):133-141. 1992 Academic Article GET IT
Times cited: 4
Periventricular hyperintensity [9]. Neurology. 1992 Letter
Posttraumatic pontine truncal sensory level. Archives of neurology. 1991 Letter GET IT
Syndrome identification case report #148: A rett-like syndrome with facial and limb anomalies. Dysmorphology and Clinical Genetics. 1991 Academic Article
Immunofluorescent characterization of retinal ganglion cell neurites cultured on substrates coated with antibodies against Thy-1. Experimental neurology. 113(3):386-390. 1991 Academic Article GET IT
Times cited: 7
Neuropathologic asymmetries in the brain of a patient with a unilateral status epilepticus. Journal of the neurological sciences. 103(2):127-135. 1991 Academic Article GET IT
Times cited: 17
Clinicopathologic correlations of cranial magnetic resonance imaging of periventricular white matter. Neurology. 40(6):911-918. 1990 Academic Article GET IT
Times cited: 85
Multifocal glioblastoma with liver metastases in the absence of surgery. Case report. Journal of neurosurgery. 71(5 Pt 1):772-776. 1989 Academic Article GET IT
Times cited: 15
Ocular stroke and carotid artery dissection. Neurology. 39(11):1462-1464. 1989 Academic Article GET IT
Times cited: 26
Monoclonal antibody to Thy-1 enhances regeneration of processes by rat retinal ganglion cells in culture. Science (New York, N.Y.). 224(4646):303-306. 1984 Academic Article GET IT
Times cited: 58
Three-dimensional structure of orthorhombic purple membrane at 6.5 A resolution. Journal of molecular biology. 163(3):451-466. 1983 Academic Article GET IT
Times cited: 11

Research

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Select federal grants awarded

Albumin in Acute Stroke (ALIAS) Trial - Part 2: A Phase III Randomized Multicenter Clinical Trial of High-Dose Human Albumin Therapy for Neuroprotection in Acute Ischemic Stroke awarded by National Institute of Neurological Disorders & Stroke Personnel 2009 - 2011
Carotid Revascularization Endarterectomy vs. Stenting Trial (CREST) awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2012 -
Stroke Hyperglycemia Insulin Network Effort awarded by National Institute of Neurological Disorders & Stroke Key Personnel 2011 - 2012
Thromboregulation in Occlusive Vascular Diseases awarded by National Heart, Lung, & Blood Institute Key Personnel 2009 -
MR RESCUE MR and Recanalization of Stroke Clots Using Embolectomy awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2009 - 2013
MR RESCUE MR and Recanalization of Stroke Clots Using Embolectomy awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2005 - 2008
Neuroprotection with Statin Therapy for Acute Recovery Trial awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2008 - 2010
SPOTRIAS: Neuroprotection with Statin Therapy for Acute Recovery Trial awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2006 - 2007
Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis (SAMMPRIS) awarded by National Institute of Neurological Disorders & Stroke Principal Investigator 2008 - 2013

Background

Primary Affiliation

Weill Cornell Medical College, Cornell University

Education and training

M.D., Harvard Medical School 1985
M.Phil., University of Cambridge (United Kingdom) 1981
B.A., Harvard College 1980