Apical versus Basal Neurogenesis Directs Cortical Interneuron Subclass Fate. Academic Article uri icon

Overview

abstract

  • Fate determination in the mammalian telencephalon, with its diversity of neuronal subtypes and relevance to neuropsychiatric disease, remains a critical area of study in neuroscience. Most studies investigating this topic focus on the diversity of neural progenitors within spatial and temporal domains along the lateral ventricles. Often overlooked is whether the location of neurogenesis within a fate-restricted domain is associated with, or instructive for, distinct neuronal fates. Here, we use in vivo fate mapping and the manipulation of neurogenic location to demonstrate that apical versus basal neurogenesis influences the fate determination of major subgroups of cortical interneurons derived from the subcortical telencephalon. Somatostatin-expressing interneurons arise mainly from apical divisions along the ventricular surface, whereas parvalbumin-expressing interneurons originate predominantly from basal divisions in the subventricular zone. As manipulations that shift neurogenic location alter interneuron subclass fate, these results add an additional dimension to the spatial-temporal determinants of neuronal fate determination.

publication date

  • October 29, 2015

Research

keywords

  • Cell Lineage
  • Cerebral Cortex
  • Interneurons
  • Neurogenesis

Identity

PubMed Central ID

  • PMC4704102

Scopus Document Identifier

  • 84946839070

Digital Object Identifier (DOI)

  • 10.1016/j.celrep.2015.09.079

PubMed ID

  • 26526999

Additional Document Info

volume

  • 13

issue

  • 6