Plasma serotonin levels are normal in pulmonary arterial hypertension. Academic Article uri icon

Overview

abstract

  • Serotonin (5-HT) has been implicated in the pathogenesis of pulmonary arterial hypertension (PAH). We hypothesized that plasma 5-HT would be elevated in PAH related to associated conditions. We performed a prospective cohort study of 21 patients with PAH undergoing initial right heart catheterization and 6 healthy controls. Platelet-free plasma 5-HT levels were similar in patients with idiopathic PAH, PAH related to associated conditions, and healthy controls. Higher 5-HT levels correlated with increased six-minute walk distance (r=0.55, p=0.04). These data suggest that plasma 5-HT levels are normal in PAH. Plasma 5-HT may therefore not be a useful biomarker in this condition.

publication date

  • February 12, 2007

Research

keywords

  • Hypertension, Pulmonary
  • Serotonin

Identity

PubMed Central ID

  • PMC2267916

Scopus Document Identifier

  • 38049050623

PubMed ID

  • 17374499

Additional Document Info

volume

  • 21

issue

  • 1