Zhang, Tuo

Publications

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selected publications

The transcription factor bmi1 increases hypoxic signaling in oral cavity epithelia. Biochimica et biophysica acta. Molecular basis of disease. 2024 Academic Article GET IT
SARS-CoV-2 infection causes dopaminergic neuron senescence. Cell stem cell. 2024 Academic Article GET IT
A pancreatic cancer organoid platform identifies an inhibitor specific to mutant KRAS. Cell stem cell. 2023 Academic Article GET IT
Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analysis Using Integrated Single Cell- and Single Nucleus-RNA Sequencing Platforms. 2023 GET IT
Checkpoint kinase 2 controls insulin secretion and glucose homeostasis. Nature chemical biology. 2023 Academic Article GET IT
An integrative single-cell multi-omics profiling of human pancreatic islets identifies T1D associated genes and regulatory signals. 2023 GET IT
A multi-stem cell basis for craniosynostosis and calvarial mineralization. Nature. 2023 Academic Article GET IT
Immunotherapy targeting different immune compartments in combination with radiation therapy induces regression of resistant tumors. Nature communications. 2023 Academic Article GET IT
Retinoic Acid Receptor β Loss in Hepatocytes Increases Steatosis and Elevates the Integrated Stress Response in Alcohol-Associated Liver Disease. International journal of molecular sciences. 2023 Academic Article GET IT
A Targetable Pathway to Eliminate TRA-1-60+/TRA-1-81+ Chemoresistant Cancer Cells. Journal of molecular cell biology. 2023 Academic Article GET IT
Meta‑analysis of randomized controlled trials comparing intracorporeal versus extracorporeal anastomosis in minimally invasive right hemicolectomy: upgrading the level of evidence. International journal of colorectal disease. 2023 Review GET IT
Times cited: 12232
Vaccinia E5 is a major inhibitor of the DNA sensor cGAS. Nature communications. 2023 Academic Article GET IT
Times cited: 6
OX40L-expressing recombinant modified vaccinia virus Ankara induces potent antitumor immunity via reprogramming Tregs. The Journal of experimental medicine. 2023 Academic Article GET IT
Times cited: 2
Single-nucleus RNA sequencing of human pancreatic islets identifies novel gene sets and distinguishes β-cell subpopulations with dynamic transcriptome profiles. Genome medicine. 2023 Academic Article GET IT
Times cited: 8
Molecular profiling of the stroke-induced alterations in the cerebral microvasculature reveals promising therapeutic candidates. Proceedings of the National Academy of Sciences of the United States of America. 2023 Academic Article GET IT
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Nature cell biology. 2023 Academic Article GET IT
Times cited: 8
Transcriptomic analysis predicts the risk of progression of premalignant lesions in human tongue. Discover. Oncology. 2023 Academic Article GET IT
Activation of the JAK/STAT Pathway Leads to BRAF Inhibitor Resistance in BRAFV600E Positive Thyroid Carcinoma. Molecular cancer research : MCR. 2023 Academic Article GET IT
Whole-genome characterization of myoepithelial carcinomas of the soft tissue. Cold Spring Harbor molecular case studies. 2022 Academic Article GET IT
A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants. Cell stem cell. 2022 Academic Article GET IT
The single-cell landscape of kidney immune cells reveals transcriptional heterogeneity in early diabetic kidney disease. Kidney international. 2022 Academic Article GET IT
Times cited: 1
Low-dose carbon monoxide suppresses metastatic progression of disseminated cancer cells. Cancer letters. 2022 Academic Article GET IT
Differential effects of macrophage subtypes on SARS-CoV-2 infection in a human pluripotent stem cell-derived model. Nature communications. 2022 Academic Article GET IT
Inflammatory Responses in the Placenta upon SARS-CoV-2 Infection Late in Pregnancy. iScience. 2022 Academic Article GET IT
A dual SHOX2:GFP; MYH6:mCherry knockin hESC reporter line for derivation of human SAN-like cells. iScience. 2022 Academic Article GET IT
Utility of multimodality molecular profiling for pediatric patients with central nervous system tumors. Neuro-oncology advances. 2022 Academic Article GET IT
Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability. Nature cell biology. 2021 Academic Article GET IT
Times cited: 16
A Retinoic Acid Receptor β2 Agonist Attenuates Transcriptome and Metabolome Changes Underlying Non-Alcohol-Associated Fatty Liver Disease. The Journal of biological chemistry. 2021 Academic Article GET IT
An airway organoid-based screen identifies a role for the HIF1α-glycolysis axis in SARS-CoV-2 infection. Cell reports. 2021 Academic Article GET IT
Methylation of dual-specificity phosphatase 4 controls cell differentiation. Cell reports. 2021 Academic Article GET IT
Times cited: 1
Cardiomyocytes recruit monocytes upon SARS-CoV-2 infection by secreting CCL2. Stem cell reports. 2021 Academic Article GET IT
SARS-CoV-2 infection induces beta cell transdifferentiation. Cell metabolism. 2021 Academic Article GET IT
Times cited: 122
An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts. Circulation research. 2021 Academic Article GET IT
Times cited: 38
Radiotherapy-exposed CD8+ and CD4+ neoantigens enhance tumor control. The Journal of clinical investigation. 2021 Academic Article GET IT
Times cited: 115
Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Nature communications. 2020 Academic Article GET IT
Times cited: 75
Common germline-somatic variant interactions in advanced urothelial cancer. Nature communications. 2020 Academic Article GET IT
Times cited: 19
Mutations in long-lived epithelial stem cells and their clonal progeny in pre-malignant lesions and in oral squamous cell carcinoma. Carcinogenesis. 2020 Academic Article GET IT
Times cited: 11
Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature. 2020 Academic Article GET IT
Times cited: 340
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis. Nature. 2020 Academic Article GET IT
Times cited: 133
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell stem cell. 2020 Academic Article GET IT
Times cited: 473
DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis. Nature communications. 2020 Academic Article GET IT
Times cited: 14
Dextran Sulfate Protects Pancreatic β-Cells, Reduces Autoimmunity, and Ameliorates Type 1 Diabetes. Diabetes. 2020 Academic Article GET IT
Times cited: 9
Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response. Oncoimmunology. 2020 Academic Article GET IT
Times cited: 15
Doxycycline-induced exogenous Bmi-1 expression enhances tumor formation in a murine model of oral squamous cell carcinoma. Cancer biology & therapy. 2020 Academic Article GET IT
Times cited: 7
Editorial: Bioinformatics Analysis of Single Cell Sequencing Data and Applications in Precision Medicine. Frontiers in genetics. 2020 Editorial Article GET IT
Times cited: 12
miR-431 Promotes Metastasis of Pancreatic Neuroendocrine Tumors by Targeting DAB2 Interacting Protein, a Ras GTPase Activating Protein Tumor Suppressor. The American journal of pathology. 2020 Academic Article GET IT
Times cited: 14
VCAM-1 Upregulation Contributes to Insensitivity of Vemurafenib in BRAF-Mutant Thyroid Cancer. Translational oncology. 2020 Academic Article GET IT
Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma. Translational oncology. 2019 Academic Article GET IT
Times cited: 24
Molecular determinants of nephron vascular specialization in the kidney. Nature communications. 2019 Academic Article GET IT
Times cited: 67
A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. eLife. 2019 Academic Article GET IT
Times cited: 32
Integrative Molecular Analysis of Patients With Advanced and Metastatic Cancer. JCO precision oncology. 2019 Academic Article GET IT
Times cited: 31
Pre- and peri-implantation Zika virus infection impairs fetal development by targeting trophectoderm cells. Nature communications. 2019 Academic Article GET IT
Times cited: 24
Altered Cervical Mucosal Gene Expression and Lower Interleukin 15 Levels in Women With Schistosoma haematobium Infection but Not in Women With Schistosoma mansoni Infection. The Journal of infectious diseases. 2019 Academic Article GET IT
Times cited: 12
The application of precision medicine in diagnosing familial Mediterranean fever. Leukemia & lymphoma. 2019 Letter GET IT
Gene Expression Differences in Host Response to Schistosoma haematobium Infection. Infection and immunity. 2018 Academic Article GET IT
Times cited: 10
A hPSC-based platform to discover gene-environment interactions that impact human β-cell and dopamine neuron survival. Nature communications. 2018 Academic Article GET IT
Times cited: 26
Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Nature medicine. 2018 Academic Article GET IT
Times cited: 615
Impaired hematopoiesis and leukemia development in mice with a conditional knock-in allele of a mutant splicing factor gene U2af1. Proceedings of the National Academy of Sciences of the United States of America. 2018 Academic Article GET IT
Times cited: 56
Discovery of a periosteal stem cell mediating intramembranous bone formation. Nature. 2018 Academic Article GET IT
Times cited: 389
Somatic Mutations in Renal Cyst Epithelium in Autosomal Dominant Polycystic Kidney Disease. Journal of the American Society of Nephrology : JASN. 2018 Academic Article GET IT
Times cited: 46
Discovery of a drug candidate for GLIS3-associated diabetes. Nature communications. 2018 Academic Article GET IT
Times cited: 45
Derivation and characterization of a UCP1 reporter human ES cell line. Stem cell research. 2018 Academic Article GET IT
Times cited: 5
Far Upstream Element-Binding Protein 1 Regulates LSD1 Alternative Splicing to Promote Terminal Differentiation of Neural Progenitors. Stem cell reports. 2018 Academic Article GET IT
Times cited: 26
Dried Blood Spot RNA Transcriptomes Correlate with Transcriptomes Derived from Whole Blood RNA. The American journal of tropical medicine and hygiene. 2018 Academic Article GET IT
Times cited: 13
Evidence for dispensability of protein kinase R in host control of tuberculosis. European journal of immunology. 2018 Academic Article GET IT
Times cited: 8
MicroRNA-155 regulates casein kinase 1 gamma 2: a potential pathogenetic role in chronic lymphocytic leukemia. Blood cancer journal. 2017 Article GET IT
Times cited: 7
ROCKII inhibition promotes the maturation of human pancreatic beta-like cells. Nature communications. 2017 Academic Article GET IT
Times cited: 64
EthSEQ: ethnicity annotation from whole exome sequencing data. Bioinformatics (Oxford, England). 2017 Academic Article GET IT
Times cited: 28
Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing. Nature medicine. 2017 Academic Article GET IT
Times cited: 262
Using hESCs to Probe the Interaction of the Diabetes-Associated Genes CDKAL1 and MT1E. Cell reports. 2017 Academic Article GET IT
Times cited: 18
Targeting Autocrine CCL5-CCR5 Axis Reprograms Immunosuppressive Myeloid Cells and Reinvigorates Antitumor Immunity. Cancer research. 2017 Academic Article GET IT
Times cited: 102
A proangiogenic signaling axis in myeloid cells promotes malignant progression of glioma. The Journal of clinical investigation. 2017 Academic Article GET IT
Times cited: 28
E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer. Cancer research. 2017 Academic Article GET IT
Times cited: 37
Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells. Scientific reports. 2017 Academic Article GET IT
Times cited: 41
Intrinsic Disorder and Semi-disorder Prediction by SPINE-D. Methods in molecular biology (Clifton, N.J.). 2017 Article GET IT
Times cited: 7
An Isogenic Human ESC Platform for Functional Evaluation of Genome-wide-Association-Study-Identified Diabetes Genes and Drug Discovery. Cell stem cell. 2016 Academic Article GET IT
Times cited: 90
Development and validation of a whole-exome sequencing test for simultaneous detection of point mutations, indels and copy-number alterations for precision cancer care. NPJ genomic medicine. 2016 Academic Article GET IT
Times cited: 63
The metabolic/pH sensor soluble adenylyl cyclase is a tumor suppressor protein. Oncotarget. 2016 Academic Article GET IT
Times cited: 17
N-methylation of a bactericidal compound as a resistance mechanism in Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 2016 Academic Article GET IT
Times cited: 70
RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis. Journal of immunology (Baltimore, Md. : 1950). 2016 Academic Article GET IT
Times cited: 59
G9a/GLP Complex Maintains Imprinted DNA Methylation in Embryonic Stem Cells. Cell reports. 2016 Academic Article GET IT
Times cited: 45
Sequence-based prediction of protein-peptide binding sites using support vector machine. Journal of computational chemistry. 2016 Academic Article GET IT
Times cited: 48
Tumour exosome integrins determine organotropic metastasis. Nature. 2015 Academic Article GET IT
Times cited: 3485
Gene expression profiling signatures for the diagnosis and prevention of oral cavity carcinogenesis-genome-wide analysis using RNA-seq technology. Oncotarget. 2015 Academic Article GET IT
Times cited: 24
Identification of Ethanol and 4-Nitroquinoline-1-Oxide Induced Epigenetic and Oxidative Stress Markers During Oral Cavity Carcinogenesis. Alcoholism, clinical and experimental research. 2015 Academic Article GET IT
Times cited: 25
A novel crosstalk between TLR4- and NOD2-mediated signaling in the regulation of intestinal inflammation. Scientific reports. 2015 Academic Article GET IT
Times cited: 31
Whole-Exome Sequencing of Metastatic Cancer and Biomarkers of Treatment Response. JAMA oncology. 2015 Academic Article GET IT
Times cited: 226
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nature cell biology. 2015 Academic Article GET IT
Times cited: 1955
Genome-Wide Profiling of TRACK Kidneys Shows Similarity to the Human ccRCC Transcriptome. Molecular cancer research : MCR. 2015 Academic Article GET IT
Times cited: 19
Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proceedings of the National Academy of Sciences of the United States of America. 2014 Academic Article GET IT
Times cited: 38
Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression. Proceedings of the National Academy of Sciences of the United States of America. 2013 Academic Article GET IT
Times cited: 70
Intrinsically semi-disordered state and its role in induced folding and protein aggregation. Cell biochemistry and biophysics. 2013 Academic Article GET IT
Times cited: 51
Analysis and prediction of RNA-binding residues using sequence, evolutionary conservation, and predicted secondary structure and solvent accessibility. Current protein & peptide science. 2010 Academic Article GET IT
Times cited: 44
Accurate prediction of protein folding rates from sequence and sequence-derived residue flexibility and solvent accessibility. Proteins. 2010 Academic Article GET IT
Times cited: 33
On the relation between residue flexibility and local solvent accessibility in proteins. Proteins. 2009 Academic Article GET IT
Times cited: 67
Sequence based residue depth prediction using evolutionary information and predicted secondary structure. BMC bioinformatics. 2008 Academic Article GET IT
Times cited: 36
Accurate sequence-based prediction of catalytic residues. Bioinformatics (Oxford, England). 2008 Academic Article GET IT
Times cited: 64
Secondary structure-based assignment of the protein structural classes. Amino acids. 2008 Academic Article GET IT
Times cited: 56

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Research

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Funding awarded

Abnormal Extracellular Vesicles and Particles from Human Islets Impact T1D progression awarded by National Institute of Diabetes & Digestive & Kidney Diseases Key Personnel 2023 - 2028

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Background

education and training

Ph.D., Nankai University (China) 2009
B.A., Nankai University (China) 2004

Contact

full name

Tuo Zhang

primary email

taz2008@med.cornell.edu

VIVO Weill Cornell Medical College

Tuo Zhang Instructor in Microbiology and Immunology

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email

Phone

Publications

selected publications

Research

Funding awarded

Background

education and training

Contact

full name

primary email