Jorge Moscat   Professor of Pathology and Laboratory Medicine

Phone
  • +1 646 962 6696

Dr. Moscat is a Cancer Biologist with expertise in the cellular and molecular mechanisms that control the initiation and progression of tumors. His laboratory focuses on liver and colorectal cancer and has made impactful contributions to understanding the metabolic and immunological landscape of these tumors and their response to immunotherapy. His research focuses on identifying non-oncogenic vulnerabilities in cancer, with a particular interest in the interface between inflammation and metabolism (https://www.moscatdiazmecolab.org). Dr. Moscat’s work led to identifying and characterizing the role of several novel signaling molecules in cancer, such as the autophagy and PB1-containing signaling adaptors p62/SQSTM1 and NBR1, and the PB1 kinases PKCζ and PKCλ/ι. Dr. Moscat regularly publishes high impact studies and has served in numerous scientific and leadership positions, including being an elected member of the prestigious European Molecular Biology Organization.

Dr. Moscat presently is the Homer T. Hirst III Professor of Oncology in Pathology and Vice-Chair for Experimental Pathology at the Weill Cornell Medical College. Before joining Cornell, Dr. Moscat served in several leadership positions at the Sanford Burnham Prebys Medical Discovery Institute in La Jolla (California), including Deputy Director of the Cancer Center and the Institute’s Director of Metabolism Initiatives. Before that, Dr. Moscat was a Professor and Chairman of the Department of Cancer and Cell Biology and Associate Director of the Cincinnati Cancer Consortium at the University of Cincinnati Medical College. He also served in several positions at the National Research Council of Spain, in which he was a Professor and Director of the Institute for Molecular Biology.

Affiliation

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Funding awarded

  • Cholesterol Metabolism in Mesenchymal Colorectal Cancer  awarded by National Cancer Institute Principal Investigator 2022 - 2027
  • Interferon regulation by NBR1-driven chaperone-mediated autophagy in stellate cells in liver cancer  awarded by National Cancer Institute Principal Investigator 2021 - 2026
  • Molecular mechanisms driving mesenchymal colorectal cancer  awarded by National Cancer Institute Principal Investigator 2021 - 2026
  • Novel Pathways in the Control of Lineage Plasticity in Neuroendocrine Prostate Cancer  awarded by National Cancer Institute Co-Investigator 2020 - 2025
  • Role of p62/SQSTM1 in obesity-induced liver cancer  awarded by National Institute of Mental Health Principal Investigator Subaward 2020 - 2022

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full name

  • Jorge Moscat

External Relationships

externalRelationships

  • Relationships and collaborations with for-profit and not-for-profit organizations are of vital importance to our faculty because these exchanges of scientific information foster innovation. As experts in their fields, WCM physicians and scientists are sought after by many organizations to consult and educate. WCM and its faculty make this information available to the public, thus creating a transparent environment.

    Consultant refers to an individual who provides expert advice to a business or entity (e.g., consulting on medical devices or pharmaceuticals)Consultant:
    Agenus Inc
    Leadership Roles refer to an individual with decision-making responsibility to an outside company (e.g., board of directors, officer, trustee)Leadership Roles:
    ZelamBio, Inc.
    Other Interests refers to miscellaneous financial interests not covered in other categories (e.g., stipends, anything of monetary value)Other Interest:
    Consejo Superior de Investigaciones Cientificas; Guidepoint Global LLC
    Ownership refers to any financial stake an individual owns in any company (e.g., stock options, equity interest)Ownership:
    ZelamBio, Inc.