Cognitive effects of cytotoxic cancer chemotherapy: Predisposing risk factors and potential treatments Review uri icon

Overview

MeSH Major

  • Antineoplastic Combined Chemotherapy Protocols
  • Cognition Disorders

abstract

  • Increasing evidence suggests that systemic cancer chemotherapy can have significant long-term effects on cognition, particularly on verbal learning, memory, attention, and speed of information processing. These deficits can be a source of significant distress to survivors. There is much less known about the mechanisms, predisposing vulnerabilities, and treatment of these deficits. We will summarize current knowledge of chemotherapy-associated cognitive deficits. Emerging theories about the role of selected genetic polymorphisms in heightening the vulnerability to chemotherapy-induced cognitive decline will be described.

publication date

  • October 2004

Research

keywords

  • Review

Identity

Language

  • eng

PubMed ID

  • 15355759

Additional Document Info

start page

  • 364

end page

  • 71

volume

  • 6

number

  • 5