Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury Academic Article uri icon

Overview

MeSH Major

  • Brain Ischemia
  • Nitric Oxide Synthase
  • Poly(ADP-ribose) Polymerases

abstract

  • The results suggest that iNOS expression contributes to the deleterious effects exerted by PARP activation in cerebral ischemia. However, iNOS activity is required for the protective effect of PARP inhibition and, conversely, PARP activity must be present for iNOS inhibition to be effective. The findings unveil a previously unrecognized deleterious interaction between iNOS and PARP that is relevant to the development of combination therapies for ischemic stroke.

publication date

  • December 2004

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/01.STR.0000147042.53659.6c

PubMed ID

  • 15514191

Additional Document Info

start page

  • 2896

end page

  • 901

volume

  • 35

number

  • 12