Phase I trial of iodine 131-labeled COL-1 in patients with gastrointestinal malignancies: Influence of serum carcinoembryonic antigen and tumor bulk on pharmacokinetics Academic Article uri icon

Overview

MeSH Major

  • Carcinoembryonic Antigen
  • Gastrointestinal Neoplasms
  • Iodine Radioisotopes
  • Radioimmunotherapy

abstract

  • 131I-COL-1 is well tolerated, except for hematologic toxicity. These data suggest that patients with highly elevated circulating CEA levels and/or increased tumor bulk may clear 131I-labeled COL-1 more rapidly from the circulation and experience less myelosuppression.

publication date

  • June 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8656248

Additional Document Info

start page

  • 1798

end page

  • 809

volume

  • 14

number

  • 6