Phase I/II study of iodine 125-labeled monoclonal antibody A33 in patients with advanced colon cancer Academic Article uri icon

Overview

MeSH Major

  • Colonic Neoplasms
  • Iodine Radioisotopes
  • Radioimmunotherapy

abstract

  • Low-energy emission radioimmunotherapy with doses of up to 350 mCi/m2 of 125I-mAb A33 did not cause bowel or bone marrow toxicity. The modest antitumor activity in these heavily pretreated patients is encouraging because of lack of toxicity at the doses studied. The long radioactivity retention in tumors suggests that isotopes with a long half-life may have a therapeutic advantage, based on calculated dose delivery to tumor versus normal tissue. Due to the low bone marrow dose, further 125I trials with humanized mAb A33 are warranted, and controlled studies must be conducted to evaluate the combination of radioimmunotherapy and chemotherapy.

publication date

  • June 1996

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed ID

  • 8656247

Additional Document Info

start page

  • 1787

end page

  • 97

volume

  • 14

number

  • 6