Strategies to enhance T-cell reconstitution in immunocompromised patients Review uri icon


MeSH Major

  • Immune System Diseases
  • T-Lymphocytes


  • Immune deficiency, together with its associated risks such as infections, is becoming an increasingly important clinical problem owing to the ageing of the general population and the increasing number of patients with HIV/AIDS, malignancies (especially those treated with intensive chemotherapy or radiotherapy) or transplants (of either solid organs or haematopoietic stem cells). Of all immune cells, T cells are the most often affected, leading to a prolonged deficiency of T cells, which has important clinical consequences. Accordingly, strategies to improve the recovery and function of T cells, as we discuss here, should have a direct impact on reducing the morbidity and mortality of many patients and should increase the efficacy of therapeutic and prophylactic vaccinations against microbial pathogens or tumours.

publication date

  • November 2004



  • Review



  • eng

Digital Object Identifier (DOI)

  • 10.1038/nri1484

PubMed ID

  • 15516965

Additional Document Info

start page

  • 856

end page

  • 67


  • 4


  • 11