Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis Academic Article uri icon

Overview

MeSH Major

  • BRCA1 Protein
  • BRCA2 Protein
  • Breast Neoplasms
  • Chromosomes, Human, Pair 6
  • Genetic Predisposition to Disease

abstract

  • Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lower risks of breast cancer (odds ratio [OR]: 0.51, 95% confidence interval [CI]: 0.27 to 0.98, P-value = 0.04) and colorectal cancer (OR: 0.66, 95% CI: 0.48 to 0.90, P-value = 0.01). We found similar magnitude inverse associations for estrogen positive (ER+ve) breast cancer and for colon cancer. Our results support a potentially causal relationship between higher physical activity levels and lower risks of breast cancer and colorectal cancer. Based on these data, the promotion of physical activity is probably an effective strategy in the primary prevention of these commonly diagnosed cancers.

authors

publication date

  • January 30, 2020

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC6992637

Digital Object Identifier (DOI)

  • 10.1038/s41467-020-14389-8

PubMed ID

  • 32001714

Additional Document Info

start page

  • 597

volume

  • 11

number

  • 1