Regional adaptations and parallel mutations in Feline panleukopenia virus strains from China revealed by nearly-full length genome analysis Academic Article uri icon


MeSH Major

  • Autophagy
  • Epithelial Cells
  • Pregnancy Complications, Infectious
  • Streptococcal Infections
  • Streptococcus agalactiae
  • Vagina


  • Protoparvoviruses, widespread among cats and wild animals, are responsible for leukopenia. Feline panleukopenia virus (FPLV) in domestic cats is genetically diverse and some strains may differ from those used for vaccination. The presence of FPLV in two domestic cats from Hebei Province in China was identified by polymerase chain reaction. Samples from these animals were used to isolate FPLV strains in CRFK cells for genome sequencing. Phylogenetic analysis was performed to compare our isolates with available sequences of FPLV, mink parvovirus (MEV) and canine parvovirus (CPV). The isolated strains were closely related to strains of FPLV/MEV isolated in the 1960s. Our analysis also revealed that the evolutionary history of FPLV and MEV is characterized by local adaptations in the Vp2 gene. Thus, it is likely that new FPLV strains are emerging to evade the anti-FPLV immune response.

publication date

  • January 2020



  • Academic Article



  • eng

PubMed Central ID

  • PMC6964837

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0227705

PubMed ID

  • 31945103

Additional Document Info

start page

  • e0227705


  • 15


  • 1