Single- versus multidose cardioplegia in adult cardiac surgery patients: A meta-analysis Academic Article uri icon


MeSH Major

  • Antineoplastic Agents
  • Carcinoma
  • Ovarian Neoplasms


  • © 2019 The American Association for Thoracic Surgery Objective: To compare outcomes of single (intervention group: del Nido [DN], and histamine–tryptophan–ketoglutarate) versus multidose (control group) cardioplegia in the adult cardiac surgery patients. Methods: Medical search engines were interrogated to identify relevant randomized controlled trials and propensity-score matched cohorts. Meta-analysis was conducted for primary (in-hospital/30-day mortality) and secondary (ischemic and cardiopulmonary bypass [CPB] times, reperfusion fibrillation, peak of cardiac enzymes, myocardial infarction) endpoints. Subgroup analyses were conducted for study design and type of intervention, and meta-regression for primary outcome included type of surgery and left ventricular ejection fraction as moderators. Results: Ten randomized controlled trials and 13 propensity-score matched cohorts were included, reporting on 5516 patients. Estimates are expressed as (parameter value [OR, odds ratio; MD, mean difference; SMD, standardized mean difference]/unit of measure [95% confidence interval], P value). DN reduced ischemic time (MD, −7.18 minutes [−12.52 to −1.84], P < .01), CPB time (MD, −10.44 minutes [−18.99 to −1.88], P .01), reperfusion fibrillation (OR, 0.16 [0.05-0.54], P < .01), and cardiac enzymes (SMD −0.17 [−0.29, 0.05], P < .01) compared with multidose cardioplegia. None of these beneficial effects were reproduced by histamine–tryptophan–ketoglutarate, which instead increased CPB time (MD, 2.04 minutes [0.73-3.37], P < .01) and reperfusion fibrillation (OR, 1.80 [1.20-2.70], P < .01). There was no difference in mortality and myocardial infarction between single and multidose, independently of type of surgery or left ventricular ejection fraction. Conclusions: DN decreases operative times, reperfusion fibrillation, and surge of cardiac enzymes compared with multidose cardioplegia.

publication date

  • January 2019



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1016/j.jtcvs.2019.07.109

Additional Document Info