Mitochondrial Hyperacetylation in the Failing Hearts of Obese Patients Mediated Partly by a Reduction in SIRT3: The Involvement of the Mitochondrial Permeability Transition Pore Academic Article uri icon

Overview

MeSH Major

  • Echocardiography
  • Stroke Volume
  • Ventricular Dysfunction, Left

abstract

  • Our results indicate that obesity reduces SIRT3 expression and that CypD hyperacetylation increases mPTP opening, suggesting that the activation of SIRT3 might be a potential target to decrease ventricular dysfunction and slow the progression of heart failure.

publication date

  • January 2019

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.33594/000000151

PubMed ID

  • 31464387

Additional Document Info

start page

  • 465

end page

  • 479

volume

  • 53

number

  • 3