Histiocytic Sarcoma Following B-Lymphoblastic Leukemia/Lymphoma
Cell Transformation, Neoplastic
Hematopoietic Stem Cells
Proto-Oncogene Proteins c-bcl-2
To our knowledge, this is the first study to demonstrate by WES that clonally related B-ALL and HS arise through divergent evolution from a common precursor. We present our findings together with a discussion of the previously reported cases of HS in patients with B-ALL.