Hypertension Contributes to Neuropathy in Patients With Type 1 Diabetes Academic Article Article uri icon


MeSH Major

  • Cornea
  • Microscopy, Confocal
  • Nerve Fibers
  • Peripheral Nervous System Diseases


  • © The Author(s) 2019. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd. BACKGROUND: Diabetic peripheral neuropathy (DPN) can lead to foot ulceration and amputation. There are currently no disease-modifying therapies for DPN. The aim of this study was to determine if hypertension contributes to DPN in patients with type 1 diabetes mellitus (T1DM). METHODS: Subjects with T1DM (n = 70) and controls (n = 78) underwent a comprehensive assessment of DPN. RESULTS: Hypertension was present in 40 of 70 T1DM subjects and 20 of 78 controls. Hypertension was associated with abnormal nerve conduction parameters (P = 0.03 to <0.001), increased vibration perception threshold (P = 0.01) and reduced corneal nerve fiber density and length (P = 0.02) in subjects with T1DM. However, after adjusting for confounding factors only tibial compound motor action potential and nerve conduction velocity were associated with hypertension (P = 0.03) and systolic blood pressure (P < 0.01 to <0.0001). Hypertension had no effect on neuropathy in subjects without diabetes. CONCLUSIONS: This study shows that hypertension is associated with impaired nerve conduction in T1DM. It supports previous small trials showing that angiotensin-converting enzyme inhibitors improve nerve conduction and advocates the need for larger clinical trials with blood pressure lowering agents in DPN.

publication date

  • July 17, 2019



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1093/ajh/hpz058

PubMed ID

  • 31013342

Additional Document Info

start page

  • 796

end page

  • 803


  • 32


  • 8