Inducible Pluripotent Stem Cell-Derived Cardiomyocytes Reveal Aberrant Extracellular Regulated Kinase 5 and Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Concomitantly Promote Hypertrophic Cardiomyopathy in RAF1-Associated Noonan Syndrome Academic Article uri icon

Overview

MeSH Major

  • Dioxygenases
  • Hematopoiesis
  • Hematopoietic Stem Cells
  • Zebrafish Proteins

abstract

  • Taken together, the results of our study identify the molecular mechanisms by which NS RAF1 mutations cause HCM and reveal downstream effectors that could serve as therapeutic targets for treatment of NS and perhaps other, more common, congenital HCM disorders.

publication date

  • July 16, 2019

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.118.037227

PubMed ID

  • 31163979

Additional Document Info

start page

  • 207

end page

  • 224

volume

  • 140

number

  • 3