Approaches to Targeting Cancer Stem Cells in Solid Tumors Academic Article Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Leukemia
  • Neoplastic Stem Cells

abstract

  • Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. CSCs are a population of self-renewing and tumor repopulating cells that have been observed in hematologic and solid tumors and their presence contributes to the development of drug resistance. The failure to eliminate CSCs with conventional therapy is one of major obstacles in the successful treatment of cancer. Several mechanisms have been described to contribute to CSCs chemoresistance properties that include the adoption of drug-efflux pumps, drug detoxification pathways, changes in metabolism, improved DNA repair mechanisms, and deregulated survival and pro-apoptotic pathways. Thus, CSCs are therefore an attractive target to develop new anti-cancer therapies.

publication date

  • January 2019

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.2174/1574888X14666190222164429

PubMed ID

  • 30806324

Additional Document Info

start page

  • 421

end page

  • 427

volume

  • 14

number

  • 5