Transcriptional profiling unveils type I and II interferon networks in blood and tissues across diseases Academic Article uri icon

Overview

MeSH Major

  • Autoimmune Diseases
  • Genes, Immunoglobulin
  • Immunoglobulin Variable Region

abstract

  • © 2019, The Author(s). Understanding how immune challenges elicit different responses is critical for diagnosing and deciphering immune regulation. Using a modular strategy to interpret the complex transcriptional host response in mouse models of infection and inflammation, we show a breadth of immune responses in the lung. Lung immune signatures are dominated by either IFN-γ and IFN-inducible, IL-17-induced neutrophil- or allergy-associated gene expression. Type I IFN and IFN-γ-inducible, but not IL-17- or allergy-associated signatures, are preserved in the blood. While IL-17-associated genes identified in lung are detected in blood, the allergy signature is only detectable in blood CD4+ effector cells. Type I IFN-inducible genes are abrogated in the absence of IFN-γ signaling and decrease in the absence of IFNAR signaling, both independently contributing to the regulation of granulocyte responses and pathology during Toxoplasma gondii infection. Our framework provides an ideal tool for comparative analyses of transcriptional signatures contributing to protection or pathogenesis in disease.

authors

publication date

  • December 2019

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1038/s41467-019-10601-6

Additional Document Info

volume

  • 10

number

  • 1