Insulin-like growth factor binding protein-1 predicts preterm premature rupture of membranes in twin pregnancies Academic Article uri icon


MeSH Major

  • Cultural Diversity
  • Education, Medical, Undergraduate
  • Education, Professional
  • Minority Groups
  • Program Evaluation


  • © 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: Mechanisms leading to preterm premature rupture of membranes (PPROM) remain incompletely defined. Based on the elevated occurrence of PPROM in twin gestations and recent studies of the involvement of insulin-like growth factor binding protein-1 (IGFBP-1) in the inhibition of collagen production we hypothesized that serum IGFBP-1 levels might be predictive of susceptibility to PPROM in women with twins. Methods: In this prospective study peripheral blood was obtained from 58 women with twin gestations prior to 20 weeks gestation and sera analyzed by ELISA for concentrations of IGFBP-1. Demographic and clinical outcome data were subsequently obtained and associations between IGFBP-1 and PPROM were analyzed by the Mann–Whitney test and receiver operator curve (ROC) analysis. Results: Eight of our subjects developed PPROM. They did not differ from the other women in demographics, medical history or current pregnancy outcome parameters. However, median IGFBP-1 levels were higher in women who subsequently developed PPROM (59.3 ng/ml) than in the other women (46.6 ng/ml) (p = 0.042). Using a cutoff value of 53.9 ng/ml the circulating IGFBP-1 level predicted development of PPROM with a sensitivity of 74%, specificity of 75%, a negative predictive value of 97% and a positive predictive value of 20%. Conclusions: Pending validation in larger studies the findings suggest that determination of serum IGFBP-1 levels in women with twin pregnancies may predict the later development of PPROM.

publication date

  • January 2019



  • Academic Article


Digital Object Identifier (DOI)

  • 10.1007/s00404-019-05214-9