Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis
© 2019 Elsevier Inc. Li et al. show that SIRT3 is required for diffuse large B cell lymphomas (DLBCLs)but not normal germinal center B cells. SIRT3 depletion induces DLBCL cell death by reducing glutamine flux to the TCA cycle and acetyl-CoA pools. They develop a sirtuin inhibitor that mimics SIRT3 depletion and kills DLBCL cells.
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