Non-oncogene Addiction to SIRT3 Plays a Critical Role in Lymphomagenesis Academic Article uri icon

Overview

MeSH Major

  • Bereavement
  • Suicide

abstract

  • © 2019 Elsevier Inc. Li et al. show that SIRT3 is required for diffuse large B cell lymphomas (DLBCLs)but not normal germinal center B cells. SIRT3 depletion induces DLBCL cell death by reducing glutamine flux to the TCA cycle and acetyl-CoA pools. They develop a sirtuin inhibitor that mimics SIRT3 depletion and kills DLBCL cells.

publication date

  • January 2019

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2019.05.002

Additional Document Info