Use of extracellular vesicles from lymphatic drainage as surrogate markers of melanoma progression and BRAF V600E mutation Academic Article uri icon

Overview

MeSH Major

  • Head and Neck Neoplasms
  • Melanoma
  • Sentinel Lymph Node Biopsy
  • Skin Neoplasms

abstract

  • © 2019 García-Silva et al. Liquid biopsies from cancer patients have the potential to improve diagnosis and prognosis. The assessment of surrogate markers of tumor progression in circulating extracellular vesicles could be a powerful non-invasive approach in this setting. We have characterized extracellular vesicles purified from the lymphatic drainage also known as exudative seroma (ES) of stage III melanoma patients obtained after lymphadenectomy. Proteomic analysis showed that seroma-derived exosomes are enriched in proteins resembling melanoma progression. In addition, we found that the BRAF V600E mutation can be detected in ES-derived extracellular vesicles and its detection correlated with patients at risk of relapse.

authors

publication date

  • May 2019

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1084/jem.20181522

PubMed ID

  • 30975894

Additional Document Info

start page

  • 1061

end page

  • 1070

volume

  • 216

number

  • 5