Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis Academic Article uri icon

Overview

MeSH Major

  • Bulbar Palsy, Progressive
  • Disease Progression

abstract

  • Here, we have developed a public resource (https://lng-nia.shinyapps.io/mrshiny) which we hope will become a valuable tool for the ALS community, and that will be expanded and updated as new data become available. Shared polygenic risk exists between ALS and educational attainment, physical activity, smoking, and tenseness/restlessness. We also found evidence that elevated low-desnity lipoprotein cholesterol is a causal risk factor for ALS. Future randomized controlled trials should be considered as a proof of causality. Ann Neurol 2019;85:470-481.

authors

publication date

  • April 2019

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC6450729

Digital Object Identifier (DOI)

  • 10.1002/ana.25431

PubMed ID

  • 30723964

Additional Document Info

start page

  • 470

end page

  • 481

volume

  • 85

number

  • 4