Sleep oscillation-specific associations with Alzheimer's disease CSF biomarkers: novel roles for sleep spindles and tau Academic Article uri icon

Overview

MeSH Major

  • Aging
  • Alzheimer Disease
  • Brain
  • Energy Metabolism
  • Perimenopause
  • Postmenopause

abstract

  • Reduced spindles during N2 sleep may represent an early dysfunction related to tau, possibly reflecting axonal damage or altered neuronal tau secretion, rendering it a potentially novel biomarker for early neuronal dysfunction. Given their putative role in memory consolidation and neuroplasticity, sleep spindles may represent a mechanism by which tau impairs memory consolidation, as well as a possible target for therapeutic interventions in cognitive decline.

publication date

  • February 21, 2019

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1186/s13024-019-0309-5

PubMed ID

  • 30791922

Additional Document Info

start page

  • 10

volume

  • 14

number

  • 1