Whole-methylome analysis of circulating monocytes in acute diabetic Charcot foot reveals differentially methylated genes involved in the formation of osteoclasts Academic Article uri icon

Overview

MeSH Major

  • Arteries
  • Metabolic Syndrome X
  • Obesity
  • Subcutaneous Fat
  • Vascular Remodeling
  • Ventricular Dysfunction, Left
  • Ventricular Function, Left

abstract

  • WM analysis demonstrated that CF monocytes are differentially methylated compared with non-CF monocytes, in both CpG-site and gene-mapped analysis approaches. Among the methylated genes, several are involved in the migration process during monocyte differentiation into osteoclasts or are indirectly involved through the regulation of inflammatory pathways. Finally, we demonstrated an association between methylation and gene expression in cis- and trans-association.

publication date

  • February 2019

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.2217/epi-2018-0144

PubMed ID

  • 30753117

Additional Document Info

start page

  • 281

end page

  • 296

volume

  • 11

number

  • 3