Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis
Antineoplastic Agents, Immunological
Cell Cycle Checkpoints
© 2019 Bacteriophages are abundant components of the gut microbiota, but how they impact health and immunity is unknown. Gogokhia et al. report that bacteriophages activate IFN-γ through a TLR9-dependent pathway and exacerbate colitis. Supporting this, increased abundance of bacteriophages in patients with ulcerative colitis correlates with mucosal IFN-γ responses.
Digital Object Identifier (DOI)
Additional Document Info
has global citation frequency