Expansion of Bacteriophages Is Linked to Aggravated Intestinal Inflammation and Colitis Academic Article uri icon

Overview

MeSH Major

  • Antineoplastic Agents, Immunological
  • Cell Cycle Checkpoints
  • Immunotherapy

abstract

  • © 2019 Bacteriophages are abundant components of the gut microbiota, but how they impact health and immunity is unknown. Gogokhia et al. report that bacteriophages activate IFN-γ through a TLR9-dependent pathway and exacerbate colitis. Supporting this, increased abundance of bacteriophages in patients with ulcerative colitis correlates with mucosal IFN-γ responses.

publication date

  • January 2019

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2019.01.008

Additional Document Info