Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Transitional Cell
  • Epitopes, T-Lymphocyte
  • Membrane Proteins
  • Proteins
  • Urinary Bladder Neoplasms

abstract

  • MSI-H/MMR-D is predictive of LS across a much broader tumor spectrum than currently appreciated. Given implications for cancer surveillance and prevention measures in affected families, these data support germline genetic assessment for LS for patients with an MSI-H/MMR-D tumor, regardless of cancer type or family cancer history.

authors

publication date

  • February 2019

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1200/JCO.18.00283

PubMed ID

  • 30376427

Additional Document Info

start page

  • 286

end page

  • 295

volume

  • 37

number

  • 4