The t(1;10)(p22;q24) TGFBR3/MGEA5 Translocation in Pleomorphic Hyalinizing Angiectatic Tumor, Myxoinflammatory Fibroblastic Sarcoma, and Hemosiderotic Fibrolipomatous Tumor Academic Article uri icon


MeSH Major

  • Aortic Aneurysm
  • Autoimmune Diseases
  • Hypergammaglobulinemia
  • Sclerosis


  • Diagnosis of HFLT, PHAT, and MIFS is challenging because of a lack of unique morphologic, immunophenotypic, molecular, and cytogenetic markers. The recurrent t(1;10)(p22;q24) translocation and/or TGFBR3/MGEA5 rearrangement was reported in 55 patients, with a relatively even distribution among HFLT, PHAT, and MIFS (17 HFLT, 15 MIFS, 13 MIFS/HFLT, and 10 PHAT). This indicates that current morphology-based diagnostic criteria do not identify reliably the subset of soft tissue tumor with t(1;10) translocation. Genetic heterogeneity of these tumors is supported by the recent detection of a mutually exclusive, second recurrent genetic change, t(7;17) TOM1L2-BRAF translocation or BRAF amplification, in a subset of MIFS.

publication date

  • February 2019



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.5858/arpa.2017-0412-RA

PubMed ID

  • 29979612

Additional Document Info

start page

  • 212

end page

  • 221


  • 143


  • 2