Isolated Abducens Nerve Palsy Following Pembrolizumab Article In process uri icon

Overview

MeSH Major

  • Diagnostic Imaging
  • Fluorescein Angiography
  • Uveitis

abstract

  • © 2019, © 2019 Taylor & Francis Group, LLC. Pembrolizumab is a checkpoint inhibitor targeting the programmed cell death 1 receptor of lymphocytes and is used in the treatment of solid tumours including melanoma. The authors report a 64-year-old man treated with pembrolizumab for stage IV cutaneous melanoma (primary cutaneous melanoma of the right lower back) with liver metastases. The patient developed a horizontal binocular diplopia due to an isolated unilateral cranial nerve VI palsy. Following 1 week of high dose oral steroid therapy and cessation of the drug, the patient’s nerve palsy and associated diplopic symptoms improved dramatically, and after 6 weeks of oral steroid taper and drug cessation, the palsy resolved completely. Few reports of checkpoint inhibitor autoimmune-induced isolated cranial nerve palsies have been described, and this is the first report of drug-induced isolated cranial nerve VI palsy.

publication date

  • January 2019

Research

keywords

  • In Process

Identity

Digital Object Identifier (DOI)

  • 10.1080/01658107.2019.1566385