Rapid automated liver quantitative susceptibility mapping Article In process uri icon


MeSH Major

  • Contrast Media
  • Gadolinium DTPA
  • Liver
  • Liver Cirrhosis


  • © 2019 International Society for Magnetic Resonance in Medicine Background: Accurate measurement of the liver iron concentration (LIC) is needed to guide iron-chelating therapy for patients with transfusional iron overload. In this work, we investigate the feasibility of automated quantitative susceptibility mapping (QSM) to measure the LIC. Purpose: To develop a rapid, robust, and automated liver QSM for clinical practice. Study Type: Prospective. Population: 13 healthy subjects and 22 patients. Field Strength/Sequences: 1.5 T and 3 T/3D multiecho gradient-recalled echo (GRE) sequence. Assessment: Data were acquired using a 3D GRE sequence with an out-of-phase echo spacing with respect to each other. All odd echoes that were in-phase (IP) were used to initialize the fat-water separation and field estimation (T2*-IDEAL) before performing QSM. Liver QSM was generated through an automated pipeline without manual intervention. This IP echo-based initialization method was compared with an existing graph cuts initialization method (simultaneous phase unwrapping and removal of chemical shift, SPURS) in healthy subjects (n = 5). Reproducibility was assessed over four scanners at two field strengths from two manufacturers using healthy subjects (n = 8). Clinical feasibility was evaluated in patients (n = 22). Statistical Tests: IP and SPURS initialization methods in both healthy subjects and patients were compared using paired t-test and linear regression analysis to assess processing time and region of interest (ROI) measurements. Reproducibility of QSM, R2*, and proton density fat fraction (PDFF) among the four different scanners was assessed using linear regression, Bland–Altman analysis, and the intraclass correlation coefficient (ICC). Results: Liver QSM using the IP method was found to be ~5.5 times faster than SPURS (P < 0.05) in initializing T2*-IDEAL with similar outputs. Liver QSM using the IP method were reproducibly generated in all four scanners (average coefficient of determination 0.95, average slope 0.90, average bias 0.002 ppm, 95% limits of agreement between –0.06 to 0.07 ppm, ICC 0.97). Data Conclusion: Use of IP echo-based initialization enables robust water/fat separation and field estimation for automated, rapid, and reproducible liver QSM for clinical applications. Level of Evidence: 1. Technical Efficacy: Stage 2. J. Magn. Reson. Imaging 2019.

publication date

  • January 2019



  • In Process


Digital Object Identifier (DOI)

  • 10.1002/jmri.26632

Additional Document Info