MicroRNAs and Transplantation Review uri icon

Overview

MeSH Major

  • Genetic Markers
  • Genetic Testing
  • Graft Rejection
  • Graft Survival
  • Kidney Transplantation
  • MicroRNAs
  • RNA, Messenger

abstract

  • miRNAs, ∼20 to 22 nucleotide single-stranded RNA species that play a pivotal role in the regulation of protein-coding genes, are emerging as robust biomarkers for assessing allograft status. Herein, the authors briefly review the biogenesis and function of the miRNAs and provide an overview of the tools to quantify miRNAs in tissues and body fluids. They then review their studies of discovery and validation of alterations in miRNA expression within kidney allografts with or without acute rejection, as well as with or without fibrosis, and summarize published data on miRNA expression patterns in kidney transplant recipients.

publication date

  • March 2019

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.cll.2018.10.003

PubMed ID

  • 30709501

Additional Document Info

start page

  • 125

end page

  • 143

volume

  • 39

number

  • 1