Phosphatidylinositol 3-kinase, growth disorders, and cancer Review uri icon

Overview

MeSH Major

  • Neoplasms
  • Phosphatidylinositol 3-Kinase

abstract

  • Copyright © 2018 Massachusetts Medical Society. PI3K is a key regulatory node in growth-factor signaling across evolution. Its importance in a wide array of physiologic processes, including insulin signaling, cell growth, immunity, and brain development, has been confirmed in animal models and humans. In particular, PI3K has held great promise as an anticancer target from the time of its initial discovery. Multiple targeted agents are now available, and we expect that they will be proved effective when coupled with strategies to minimize insulin feedback.

publication date

  • November 22, 2018

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1056/NEJMra1704560

PubMed ID

  • 30462943

Additional Document Info

start page

  • 2052

end page

  • 2062

volume

  • 379

number

  • 21