Regional differences in gallbladder cancer pathogenesis: Insights from a multi-institutional comparison of tumor mutations Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Indoles
  • Melanoma
  • Proto-Oncogene Proteins B-raf
  • Sulfonamides

abstract

  • Differences in clinicopathologic variables suggest the possibility of distinct GBCA pathogenesis in Japanese patients, which may be supported by differences in mutation pattern. Among all centers, SMAD4 mutations were detected in approximately one-third of patients and may represent a converging factor associated with worse survival. The majority of patients carried mutations in actionable gene targets, which may inform the design of future trials.

publication date

  • February 15, 2019

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1002/cncr.31850

PubMed ID

  • 30427539

Additional Document Info

start page

  • 575

end page

  • 585

volume

  • 125

number

  • 4