Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: Potential novel therapeutic targets 11 Medical and Health Sciences 1109 Neurosciences Academic Article uri icon

Overview

MeSH Major

  • Aging
  • Alzheimer Disease
  • Brain
  • Energy Metabolism
  • Perimenopause
  • Postmenopause

abstract

  • The PGJ2-induced rat model develops progressive PD pathology, which is a hard-to-mimic aspect of this disorder. Moreover, prevention of most PGJ2-induced PD-like pathology with ibuprofen suggests a positive feedback mechanism between PGJ2 and COX-2 that could lead to chronic neuroinflammation. Notably, this is the first study that analyzes the nigral dopaminergic and microglial distribution and levels of factors of the PGD2/J2 signaling pathway in rodents. Our findings support the notions that upregulation of COX-2 and L-PGDS may be important in the PGJ2 evoked PD-like pathology, and that neuronal DP2 receptor antagonists and L-PGDS inhibitors may be novel pharmacotherapeutics to relieve neuroinflammation-mediated neurodegeneration in PD, circumventing the adverse side effects of cyclooxygenase inhibitors.

publication date

  • September 20, 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC6146649

Digital Object Identifier (DOI)

  • 10.1186/s12974-018-1305-3

PubMed ID

  • 30236122

Additional Document Info

start page

  • 272

volume

  • 15

number

  • 1