Secreted IgD Amplifies Humoral T Helper 2 Cell Responses by Binding Basophils via Galectin-9 and CD44 Academic Article uri icon


MeSH Major

  • Gene Expression Regulation
  • Germ Cells
  • Intercellular Signaling Peptides and Proteins
  • Oxidoreductases Acting on Sulfur Group Donors
  • Triticum


  • B cells thwart antigenic aggressions by releasing immunoglobulin M (IgM), IgG, IgA, and IgE, which deploy well-understood effector functions. In contrast, the role of secreted IgD remains mysterious. We found that some B cells generated IgD-secreting plasma cells following early exposure to external soluble antigens such as food proteins. Secreted IgD targeted basophils by interacting with the CD44-binding protein galectin-9. When engaged by antigen, basophil-bound IgD increased basophil secretion of interleukin-4 (IL-4), IL-5, and IL-13, which facilitated the generation of T follicular helper type 2 cells expressing IL-4. These germinal center T cells enhanced IgG1 and IgE but not IgG2a and IgG2b responses to the antigen initially recognized by basophil-bound IgD. In addition, IgD ligation by antigen attenuated allergic basophil degranulation induced by IgE co-ligation. Thus, IgD may link B cells with basophils to optimize humoral T helper type 2-mediated immunity against common environmental soluble antigens.

publication date

  • October 16, 2018



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2018.08.013

PubMed ID

  • 30291028

Additional Document Info

start page

  • 709

end page

  • 724.e8


  • 49


  • 4