On cell death in the intestinal epithelium and its impact on gut homeostasis Academic Article uri icon

Overview

MeSH Major

  • Bacteria
  • Immunity, Innate
  • Microbial Viability
  • RNA, Bacterial
  • RNA, Messenger
  • Receptors, Pattern Recognition

abstract

  • Excessive IEC death and loss-of-barrier function is characteristic of IBD. As regulatory and tolerogenic mechanisms are broken in IBD, a molecular understanding of the precise triggers and modes of IEC death as well as their consequences on intestinal inflammation is necessary. This characterization should guide new therapies that restore homeostatic apoptosis, along with its associated programs of immune tolerance and immunosuppression, to achieve mucosal healing and long-term remission.

publication date

  • November 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1097/MOG.0000000000000481

PubMed ID

  • 30169459

Additional Document Info

start page

  • 413

end page

  • 419

volume

  • 34

number

  • 6