Methodological Issues in Studying PAHSA Biology: Masking PAHSA Effects Letter uri icon

Overview

MeSH Major

  • Endocytosis
  • Metabolic Networks and Pathways

abstract

  • PAHSAs are anti-diabetic and anti-inflammatory lipids. Syed et al. identify numerous experimental differences that likely account for the failure of Pflimlin et al. to observe PAHSA beneficial effects. The differences include different HFDs resulting in minimal/no glucose intolerance, different assay conditions, an LC-MS protocol that was not validated, and use of olive oil, a bioactive nutrient that improves glucose tolerance, as a vehicle.

publication date

  • October 2, 2018

Research

keywords

  • Letter

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.cmet.2018.09.007

PubMed ID

  • 30244974

Additional Document Info

start page

  • 543

end page

  • 546

volume

  • 28

number

  • 4