Converging pathways in neurodegeneration, from genetics to mechanisms Review uri icon

Overview

MeSH Major

  • Alzheimer Disease
  • Memory Disorders
  • Protein Processing, Post-Translational
  • Tauopathies
  • tau Proteins

abstract

  • Neurodegenerative diseases cause progressive loss of cognitive and/or motor function and pose major challenges for societies with rapidly aging populations. Human genetics studies have shown that disease-causing rare mutations and risk-associated common alleles overlap in different neurodegenerative disorders. Here we review the intricate genotype-phenotype relationships and common cellular pathways emerging from recent genetic and mechanistic studies. Shared pathological mechanisms include defective protein quality-control and degradation pathways, dysfunctional mitochondrial homeostasis, stress granules, and maladaptive innate immune responses. Research efforts have started to bear fruit, as shown by recent treatment successes and an encouraging therapeutic outlook.

publication date

  • October 2018

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/s41593-018-0237-7

PubMed ID

  • 30258237

Additional Document Info

start page

  • 1300

end page

  • 1309

volume

  • 21

number

  • 10