Sino-Orbital Fungal Infection by Tilletiopsis minor, a Rare Human Pathogen, Diagnosed by Internal Transcribed Spacer Sequencing Academic Article uri icon


MeSH Major

  • Basidiomycota
  • Eye Infections, Fungal
  • Orbital Diseases
  • Paranasal Sinus Diseases


  • Orbital infection can be caused by numerous pathogens, and accurate diagnosis informs appropriate therapy. The authors report a case of a 78-year-old man with well-controlled diabetes mellitus and recurrent sino-orbital infection following multiple surgical procedures with negative microbiologic results. This case presented a diagnostic and treatment challenge and was aided by the use of internal transcribed spacer sequencing for pathogen identification. The fungal pathogen, Tilletiopsis minor, has not previously been described as a human pathogen in the sinus and orbit. This report describes a novel orbital pathogen and highlights the importance of diagnostic diligence and utilizing internal transcribed spacer sequencing in the workup of atypical orbital infection.

publication date

  • September 2018



  • Academic Article



  • eng

Digital Object Identifier (DOI)

  • 10.1097/IOP.0000000000001186

PubMed ID

  • 30198982

Additional Document Info

start page

  • e162

end page

  • e164


  • 34


  • 5