Genome-wide association study of lung function and clinical implication in heavy smokers Academic Article uri icon

Overview

MeSH Major

  • Epigenesis, Genetic
  • Epithelium
  • Smoking

abstract

  • This study is the first to show genome-wide significant association of rs28929474 in SERPINA1 with lung function. Of clinical importance, heterozygotes of rs28929474 (4.7% of subjects) have significantly reduced pulmonary function, demonstrating a major impact in smokers. The multi-gene model is significantly associated with CT-based emphysema and clinical outcome measures of severity. Combining genetic information with demographic and environmental factors will further increase the predictive power for assessing reduced lung function and COPD severity.

authors

publication date

  • August 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1186/s12881-018-0656-z

PubMed ID

  • 30068317

Additional Document Info

start page

  • 134

volume

  • 19

number

  • 1