A model for determining an effective in vivo dose of transplanted islets based on in vitro insulin secretion Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Renal Cell
  • Cell Culture Techniques
  • Kidney Neoplasms

abstract

  • Increasing dosages of islet macrobeads transplanted into diabetic rats, based on multiples of in vitro insulin secretion matched to the recipient's exogenous insulin requirements, correlated with improved blood glucose regulation and increased duration of graft function. These results demonstrate the usefulness of a standardized model for the evaluation of the functional effectiveness of islets intended for transplantation, in this case using intraperitoneally implanted agarose macrobeads, in diabetic rats. The results suggest that some features of this islet-dosing methodology may be applicable, and indeed necessary, to clinical allogeneic and xenogeneic islet transplantation.

publication date

  • January 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1111/xen.12443

PubMed ID

  • 30054944

Additional Document Info

start page

  • e12443