Lifestyle and vascular risk effects on MRI-based biomarkers of Alzheimer's disease: A cross-sectional study of middle-aged adults from the broader New York City area Academic Article uri icon

Overview

MeSH Major

  • Alzheimer Disease
  • Biomarkers
  • Brain
  • Diet, Mediterranean
  • Life Style

abstract

  • In cognitively normal middle-aged adults, MeDi and insulin sensitivity explained cortical thickness in key brain regions for AD, and EC thickness predicted memory performance in turn. Intellectual activity and overweight were associated with cognitive performance through different pathways. Our findings support further investigation of lifestyle and vascular risk factor modification against brain ageing and AD. More studies with larger samples are needed to replicate these research findings in more diverse, community-based settings.

publication date

  • March 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5875649

Digital Object Identifier (DOI)

  • 10.1136/bmjopen-2017-019362

PubMed ID

  • 29574441

Additional Document Info

start page

  • e019362

volume

  • 8

number

  • 3