Exercise therapy and cardiovascular toxicity in cancer Review uri icon


MeSH Major

  • Exercise Therapy
  • Prostatic Neoplasms


  • Cardio-oncology is an emerging discipline focused predominantly on the detection and management of cancer treatment-induced cardiac dysfunction (cardiotoxicity), which predisposes to development of overt heart failure or coronary artery disease. The direct adverse consequences, as well as those secondary to anticancer therapeutics, extend beyond the heart, however, to affect the entire cardiovascular-skeletal muscle axis (ie, whole-organism cardiovascular toxicity). The global nature of impairment creates a strong rationale for treatment strategies that augment or preserve global cardiovascular reserve capacity. In noncancer clinical populations, exercise training is an established therapy to improve cardiovascular reserve capacity, leading to concomitant reductions in cardiovascular morbidity and its attendant symptoms. Here, we overview the tolerability and efficacy of exercise on cardiovascular toxicity in adult patients with cancer. We also propose a conceptual research framework to facilitate personalized risk assessment and the development of targeted exercise prescriptions to optimally prevent or manage cardiovascular toxicity after a cancer diagnosis.

publication date

  • January 2018



  • Review



  • eng

PubMed Central ID

  • PMC6028047

Digital Object Identifier (DOI)

  • 10.1161/CIRCULATIONAHA.117.024671

PubMed ID

  • 29530893

Additional Document Info

start page

  • 1176

end page

  • 1191


  • 137


  • 11