Metabolic imaging of the human brain with hyperpolarized13C Pyruvate demonstrates13C lactate production in brain tumor patients Academic Article uri icon

Overview

MeSH Major

  • Brain Neoplasms
  • Glioblastoma
  • Receptor Protein-Tyrosine Kinases
  • Sequence Deletion

abstract

  • ©2018 American Association for Cancer Research. Hyperpolarized (HP) MRI using [1-13C] pyruvate is a novel method that can characterize energy metabolism in the human brain and brain tumors. Here, we present the first dynamically acquired human brain HP 13C metabolic spectra and spatial metabolite maps in cases of both untreated and recurrent tumors. In vivo production of HP lactate from HP pyruvate by tumors was indicative of altered cancer metabolism, whereas production of HP lactate in the entire brain was likely due to baseline metabolism. We correlated our results with standard clinical brain MRI, MRI DCE perfusion, and in one case FDG PET/ CT. Our results suggest that HP 13C pyruvate-to-lactate conversion may be a viable metabolic biomarker for assessing tumor response. Significance: Hyperpolarized pyruvate MRI enables metabolic imaging in the brain and can be a quantitative biomarker for active tumors.

publication date

  • July 15, 2018

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC6050093

Digital Object Identifier (DOI)

  • 10.1158/0008-5472.CAN-18-0221

PubMed ID

  • 29769199

Additional Document Info

start page

  • 3755

end page

  • 3760

volume

  • 78

number

  • 14